Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
Belongs to the FIS1 family. Contains 1 TPR repeat.
The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L.
Western blot - Anti-TTC11 antibody - N-terminal (ab189846)
All lanes : Anti-TTC11 / FIS1 antibody - N-terminal (ab189846) at 1/500 dilution
Lane 1 : 293T cell line extract Lane 2 : HepG2 cell line extract Lane 3 : A549 cell line extract Lane 4 : HeLa cell line extract Lane 5 : MCF7 cell line extract Lane 6 : Mouse spleen cell line extract Lane 7 : Mouse kidney cell line extract