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Rabbit polyclonal to TTC3
Reacts specifically with human 229 kDa TTC3 protein.
Synthetic peptide derived from the N terminal domain of Human TTC3
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: Whole serum
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
1/500 - 1/5000. Predicted molecular weight: 230 kDa.
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
Found in all tissues examined.
Protein modification; protein ubiquitination.
Contains 1 RING-type zinc finger.
Contains 4 TPR repeats.
Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.
Information by UniProt
E3 ubiquitin protein ligase TTC3 antibody
E3 ubiquitin-protein ligase TTC3 antibody
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"