Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab187893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-TTF1 antibody [EP1584Y] (ab76013)

  • Form

    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names

    • AV026640
    • BCH
    • Benign chorea
    • BHC
    • Homeobox protein NK 2 homolog A
    • Homeobox protein NK-2 homolog A
    • Homeobox protein Nkx 2.1
    • Homeobox protein Nkx-2.1
    • Homeobox protein Nkx2.1
    • NK 2
    • NK 2 homolog A
    • NK2
    • NK2 homeobox 1
    • NK2, drosophila, homolog of, A
    • NK2.1, mouse, homolog of
    • Nkx 2 1
    • NKX 2.1
    • NKX 2A
    • NKX2 1
    • Nkx2-1
    • NKX2.1
    • NKX21_HUMAN
    • NKX2A
    • T EBP
    • T/EBP
    • TEBP
    • Thyroid nuclear factor
    • Thyroid nuclear factor 1
    • Thyroid specific enhancer binding protein
    • Thyroid transcription factor 1
    • Tin man
    • Tinman
    • TITF 1
    • TITF1
    • TTF 1
    • TTF-1
    • TTF1
    see all
  • Function

    Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis.
  • Tissue specificity

    Thyroid and lung.
  • Involvement in disease

    Defects in NKX2-1 are the cause of benign hereditary chorea (BHC) [MIM:118700]; also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances.
    Defects in NKX2-1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD) [MIM:610978]. This syndrome include neurological, thyroid, and respiratory problems.
  • Sequence similarities

    Belongs to the NK-2 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Post-translational
    modifications

    Phosphorylated on serine residues.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab187893 has not yet been referenced specifically in any publications.

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