Product nameTTFA, Mitochondrial Complex II inhibitor
DescriptionMitochondrial Complex II inhibitor
Blocks respiratory chain complex II causing inhibition of mitochondrial respiration in animals and bacteria. Binds to two ubiquinone binding sites, Qp and Qd, causing respiratory chain complex II inhibition. Delays overall cell cycle progression leading to oxidative stress. Also inhibits porcine liver carboxylesterase (IC50 = 0.54 µM).
Storage instructionsShipped at room temperature. Store at -20°C.
Soluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Siebels I & Dröse S Q-site inhibitor induced ROS production of mitochondrial complex II is attenuated by TCA cycle dicarboxylates. Biochim Biophys Acta 1827:1156-64 (2013). Read more (PubMed: 23800966) »
- Byun HO et al. Mitochondrial dysfunction by complex II inhibition delays overall cell cycle progression via reactive oxygen species production. J Cell Biochem 104:1747-59 (2008). Read more (PubMed: 18395845) »
- Sun F et al. Crystal structure of mitochondrial respiratory membrane protein complex II. Cell 121:1043-57 (2005). Read more (PubMed: 15989954) »
- Zhang JG & Fariss MW Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity. Biochem Pharmacol 63:751-4 (2002). Read more (PubMed: 11992644) »