Polyglutamylase which preferentially modifies beta-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for neurite growth.
Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum.
Belongs to the tubulin--tyrosine ligase family. Contains 1 TTL domain.
Cell projection > cilium. Cytoplasm > cytoskeleton > cilium basal body. Cell projection > dendrite. Perikaryon. In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon.