Overview

  • Product name

    Tubacin, HDAC6 inhibitor
  • Description

    Potent and selective HDAC6 inhibitor
  • Biological description

    Potent and selective HDAC6 inhibitor (IC50 = 4 nM). Inhibits second deacetylase domain (DD2). Reversibly inhibits α-tubulin deacetylation. Induces expression of the transcription factor DDIT3 (CHOP/GADD153). Inhibits migration of wild-type and HCAC6 overexpressing cells. Inhibits replication of Japanese Encephalitis Virus via a reduction in viral RNA synthesis.

  • Purity

    > 98%
  • CAS Number

    537049-40-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[4-[(2R,4R,6S)-4-[(4,5-Diphenyl-1,3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
  • Molecular weight

    721.86
  • Molecular formula

    C41H43N3O7S
  • PubChem identifier

    6675804
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C(OC(OC1C2=CC=C(C=C2)CO)C3=CC=C(C=C3)NC(=O)CCCCCCC(=O)NO)CSC4=NC(=C(O4)C5=CC=CC=C5)C6=CC=CC=C6
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lu CY  et al. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Int J Mol Sci 18:N/A (2017). Read more (PubMed: 28468311) »
  • Aldana-Masangkay GI  et al. Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Leuk Lymphoma 52:1544-55 (2011). Read more (PubMed: 21699378) »
  • Namdar M  et al. Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc Natl Acad Sci U S A 107:20003-8 (2010). Read more (PubMed: 21037108) »
  • Tran AD  et al. HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell Sci 120:1469-79 (2007). Read more (PubMed: 17389687) »

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