Overview

  • Product name

    Tubastatin A hydrochloride, HDAC6 inhibitor
  • Description

    Potent, selective HDAC6 inhibitor
  • Biological description

    Potent, selective HDAC6 inhibitor (IC50 values are 4 and 900 nM for HDAC6 and HDAC8 respectively). Inhibits LPS-induced cytokine production in macrophages (IC50 values are 272 and 712 nM for TNF-α and IL-6 respectively). Induces α-tubulin hyperacetylation. Shows anti-inflammatory and peripheral neuroprotective effects in vivo.
  • Purity

    > 98%
  • CAS Number

    1239262-52-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Jochems J  et al. Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability. Neuropsychopharmacology 39:389-400 (2014). Read more (PubMed: 23954848) »
  • Zhang D  et al. Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of a-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation. Circulation 129:346-58 (2014). Read more (PubMed: 24146251) »
  • Vishwakarma S  et al. Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects. Int Immunopharmacol 16:72-8 (2013). Read more (PubMed: 23541634) »

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