Anti-TUSC2/FUS1 antibody (ab246970)

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Overview

  • Product name

    Anti-TUSC2/FUS1 antibody
    See all TUSC2/FUS1 primary antibodies

  • Description

    Rabbit polyclonal to TUSC2/FUS1

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WB, ICC/IFmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse

  • Immunogen

    Recombinant fragment corresponding to Human TUSC2/FUS1 aa 4-106.
    Sequence:

    SGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFVFTRRGSMFY DEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIHVDF PVI


    Database link: O75896

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • WB: HEK-293T overexpressing TUSC2/FUS1 with a C-terminal myc-DDK tag, whole cell lysate. ICC/IF: A431 cells.

  • General notes

     This product was previously labelled as TUSC2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab246970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.4 µg/ml. Predicted molecular weight: 12 kDa.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100

Target

  • Function

    May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

  • Tissue specificity

    Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.

  • Sequence similarities

    Belongs to the TUSC2 family.

  • Post-translational
    modifications

    Myristoylation is required for tumor suppressor activity.
  • Information by UniProt

  • Database links

    • Alternative names

      • C3orf11 antibody
      • Fus-1 protein antibody
      • FUS1 antibody
      • Fusion 1 protein antibody
      • LGCC antibody
      • PAP antibody
      • PDAP2 antibody
      • PDGFA associated protein 2 antibody
      • PDGFA-associated protein 2 antibody
      • Tumor suppressor candidate 2 antibody
      • TUSC 2 antibody
      • Tusc2 antibody
      • TUSC2_HUMAN antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-TUSC2/FUS1 antibody (ab246970)
      Immunocytochemistry/ Immunofluorescence - Anti-TUSC2/FUS1 antibody (ab246970)

      PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for TUSC2/FUS1 (green) using ab246970 at 4 μg/ml in ICC/IF.

    • Western blot - Anti-TUSC2/FUS1 antibody (ab246970)
      Western blot - Anti-TUSC2/FUS1 antibody (ab246970)
      All lanes : Anti-TUSC2/FUS1 antibody (ab246970) at 0.4 µg/ml

      Lane 1 : Vextor only transfected HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
      Lane 2 : HEK-293T overexpressing TUSC2/FUS1 with a C-terminal myc-DDK tag, whole cell lysate.

      Predicted band size: 12 kDa

    References

    ab246970 has not yet been referenced specifically in any publications.

    Publishing research using ab246970? Please let us know so that we can cite the reference in this datasheet.

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