Overview

  • Product name

    Anti-TXNRD3 antibody
  • Description

    Rabbit polyclonal to TXNRD3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rabbit
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 70-119 (LSPPGRRARL SSPGPSRSSE AREELRRHLV GLIERSRVVI FSKSYCPHST) of Human TXNRD3.

  • Positive control

    • OVCAR-3 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab134034 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 75 kDa.

Target

  • Function

    Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.
  • Sequence similarities

    Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
    Contains 1 glutaredoxin domain.
  • Domain

    The N-terminal glutaredoxin domain does not contain the C-X-X-C redox-active motif normally found in glutaredoxins but activity may be mediated through a single cysteine. The C-terminal Cys-Sec motif of one subunit of the homodimer may transfer electrons from the thiol-disulfide center to the glutaredoxin domain of the other subunit.
  • Cellular localization

    Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Detected in cytoplasm and nucleus in late spermatids.
  • Information by UniProt
  • Database links

  • Alternative names

    • TGR antibody
    • Thioredoxin and glutathione reductase antibody
    • Thioredoxin glutathione reductase antibody
    • Thioredoxin reductase 2 antibody
    • Thioredoxin reductase 3 antibody
    • Thioredoxin reductase TR2 antibody
    • TR2 antibody
    • TRXR3 antibody
    • TRXR3_HUMAN antibody
    • TXNRD3 antibody
    see all

Images

  • Anti-TXNRD3 antibody (ab134034) at 1 µg/ml + OVCAR-3 cell lysate at 10 µg

    Predicted band size: 75 kDa

References

ab134034 has not yet been referenced specifically in any publications.

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