Anti-TYK2 (phospho Y292) antibody (ab138394)

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Western blot - Anti-TYK2 (phospho Y292) antibody (ab138394)

    Key features and details

    • Rabbit polyclonal to TYK2 (phospho Y292)
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-TYK2 (phospho Y292) antibody
      See all TYK2 primary antibodies

    • Description

      Rabbit polyclonal to TYK2 (phospho Y292)

    • Host species

      Rabbit

    • Specificity

      ab138394 detects endogenous levels of TYK2 only when phosphorylated at Tyr292.

    • Tested applications

      Suitable for: WBmore details

    • Species reactivity

      Reacts with: Human

    • Immunogen

      Synthetic phosphopeptide derived from Human TYK2 around the phosphorylation site of Tyr292.

    • Positive control

      • 293 cell extracts.

    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid

    • Storage instructions

      Shipped at 4°C. Store at -20ºC.

    • Storage buffer

      pH: 7.40
      Preservative: 0.02% Sodium azide
      Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)

      PBS without Mg2+ or Ca2+
    • Concentration information loading...

    • Purity

      Immunogen affinity purified

    • Purification notes

      ab138394 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation.

    • Clonality

      Polyclonal

    • Isotype

      IgG

    • Research areas

    Applications

    Our Abpromise guarantee covers the use of ab138394 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB 1/500 - 1/1000. Predicted molecular weight: 134 kDa.

    Target

    • Function

      Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

    • Tissue specificity

      Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.

    • Involvement in disease

      Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.

    • Sequence similarities

      Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
      Contains 1 FERM domain.
      Contains 1 protein kinase domain.
      Contains 1 SH2 domain.

    • Domain

      The FERM domain mediates interaction with JAKMIP1.
    • Information by UniProt

    • Database links

      • Alternative names

        • JTK 1 antibody
        • JTK1 antibody
        • Non receptor tyrosine protein kinase 2 antibody
        • Non receptor tyrosine protein kinase TYK2 antibody
        • Non-receptor tyrosine-protein kinase TYK2 antibody
        • OTTHUMP00000232745 antibody
        • OTTHUMP00000232746 antibody
        • OTTHUMP00000232748 antibody
        • Protein Tyrosine Kinase 2 antibody
        • TYK 2 antibody
        • Tyk2 antibody
        • TYK2_HUMAN antibody
        • Tyrosine kinase 2 antibody
        see all

      Images

      • Western blot - Anti-TYK2 (phospho Y292) antibody (ab138394)
        Western blot - Anti-TYK2 (phospho Y292) antibody (ab138394)
        Anti-TYK2 (phospho Y292) antibody (ab138394) at 1/500 dilution + 293 cell extract at 30 µg

        Predicted band size: 134 kDa

      References (1)

      Publishing research using ab138394? Please let us know so that we can cite the reference in this datasheet.

      ab138394 has been referenced in 1 publication.

      • Yin D  et al. Pro-Angiogenic Role of LncRNA HULC in Microvascular Endothelial Cells via Sequestrating miR-124. Cell Physiol Biochem 50:2188-2202 (2018). PubMed: 30415256

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