Anti-TYK2 (phospho Y292) antibody (ab138394)
- Datasheet
- References (1)
- Protocols
Overview
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Product name
Anti-TYK2 (phospho Y292) antibody
See all TYK2 primary antibodies -
Description
Rabbit polyclonal to TYK2 (phospho Y292) -
Host species
Rabbit -
Specificity
ab138394 detects endogenous levels of TYK2 only when phosphorylated at Tyr292. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic phosphopeptide derived from Human TYK2 around the phosphorylation site of Tyr292.
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Positive control
- 293 cell extracts.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
Note: PBS without Mg2+ or Ca2+ -
Concentration information loading... -
Purity
Immunogen affinity purified -
Purification notes
ab138394 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab138394 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500 - 1/1000. Predicted molecular weight: 134 kDa. |
Target
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Function
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. -
Tissue specificity
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines. -
Involvement in disease
Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain. -
Domain
The FERM domain mediates interaction with JAKMIP1. - Information by UniProt
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Database links
- Entrez Gene: 7297 Human
- Omim: 176941 Human
- SwissProt: P29597 Human
- Unigene: 75516 Human
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Alternative names
- JTK 1 antibody
- JTK1 antibody
- Non receptor tyrosine protein kinase 2 antibody
see all
Images
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Western blot - Anti-TYK2 (phospho Y292) antibody (ab138394)Anti-TYK2 (phospho Y292) antibody (ab138394) at 1/500 dilution + 293 cell extract at 30 µg
Predicted band size: 134 kDa
Protocols
Datasheets and documents
References
This product has been referenced in:
- Yin D et al. Pro-Angiogenic Role of LncRNA HULC in Microvascular Endothelial Cells via Sequestrating miR-124. Cell Physiol Biochem 50:2188-2202 (2018). Read more (PubMed: 30415256) »
