Overview

  • Product name

    Tylosin phosphate, Macrolide antibiotic agent
  • Description

    Macrolide antibiotic agent. Protein synthesis inhibitor.
  • Biological description

    Macrolide antibiotic agent. Protein synthesis inhibitor. Inhibits ribosomal translocation. Prevents peptidyltransferase from adding the growing peptide attached to tRNA to the next amino acid. Shows bactericidal effects in vivo. Orally active.
  • Purity

    > 90%
  • CAS Number

    1405-53-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde phosphate
  • Molecular weight

    1014.10
  • Molecular formula

    C46H77NO17.H3PO4
  • PubChem identifier

    6440844
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.OP(=O)(O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ji LW  et al. Comparative pharmacokinetics and bioavailability of tylosin tartrate and tylosin phosphate after a single oral and i.v. administration in chickens. J Vet Pharmacol Ther 37:312-5 (2014). Read more (PubMed: 24325541) »
  • Merson-Davies LA & Cundliffe E Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome. Mol Microbiol 13:349-55 (1994). Read more (PubMed: 7984112) »
  • Nakura H  et al. Formation of an antibacterial metabolite from a new macrolide compound 23-O-benzyl-5-mycaminosyl-tylonolide (TMC-101), by a hepatic microsomal drug-metabolizing enzyme system. J Pharmacobiodyn 14:377-83 (1991). Read more (PubMed: 1802985) »

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