Overview

  • Product name

    Tyrophostin AG1295, PGDF receptor inhibitor
  • Description

    Selective PGDF receptor inhibitor
  • Biological description

    Selective PGDF receptor inhibitor. Inhibits PDGF induced receptor autophosphorylation (IC50 = 300 ~ 500 nM).
  • Purity

    > 98%
  • CAS Number

    70897-07-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,7-Dimethyl-2-phenylquinoxaline
  • Molecular weight

    234.30
  • Molecular formula

    C16H14N2
  • PubChem identifier

    2048
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC2=NC=C(N=C2C=C1C)C3=CC=CC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Levitzki A PDGF receptor kinase inhibitors for the treatment of restenosis. Cardiovasc Res 65:581-6 (2005). Read more (PubMed: 15664384) »
  • Iwamoto H  et al. Platelet-derived growth factor receptor tyrosine kinase inhibitor AG1295 attenuates rat hepatic stellate cell growth. J Lab Clin Med 135:406-12 (2000). Read more (PubMed: 10811056) »
  • Banai S  et al. PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine. Circulation 97:1960-9 (1998). Read more (PubMed: 9609090) »
  • Kovalenko M  et al. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res 54:6106-14 (1994). Read more (PubMed: 7954456) »
See all 2 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142375.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up