Overview

  • Product name

    Anti-Tyrosine Hydroxylase antibody [TOH A1.1]
    See all Tyrosine Hydroxylase primary antibodies
  • Description

    Mouse monoclonal [TOH A1.1] to Tyrosine Hydroxylase
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Fr, ICC/IF, Electron Microscopymore details
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    Full length native Rat Tyrosine Hydroxylase protein (purified).

  • General notes


    ab150659 reacts with tyrosine hydroxylase immunoreactive sites in the known catecholaminergic neurons and and fibre systems of rat brain. It recognizes best the configuration of tyrosine hydroxylase in fixed tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab150659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.
Electron Microscopy Use at an assay dependent concentration.

Target

  • Function

    Plays an important role in the physiology of adrenergic neurons.
  • Tissue specificity

    Mainly expressed in the brain and adrenal glands.
  • Pathway

    Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
  • Involvement in disease

    Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
    Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
  • Sequence similarities

    Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • Dystonia 14 antibody
    • DYT14 antibody
    • DYT5b antibody
    • EC 1.14.16.2 antibody
    • OTTHUMP00000011225 antibody
    • OTTHUMP00000011226 antibody
    • ple antibody
    • Protein Pale antibody
    • TH antibody
    • The antibody
    • TY3H_HUMAN antibody
    • TYH antibody
    • Tyrosine 3 hydroxylase antibody
    • Tyrosine 3 monooxygenase antibody
    • Tyrosine 3-hydroxylase antibody
    • Tyrosine 3-monooxygenase antibody
    • Tyrosine hydroxylase antibody
    see all

References

This product has been referenced in:

  • Melander T  et al. Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS. J Neurosci 6:3640-54 (1986). ICC/IF ; Rat . Read more (PubMed: 2432203) »
  • Semenenko FM  et al. A monoclonal antibody against tyrosine hydroxylase: application in light and electron microscopy. J Histochem Cytochem 34:817-21 (1986). ICC/IF, IHC-P ; Rat . Read more (PubMed: 2871071) »
See all 2 Publications for this product

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