Recombinant
RabMAb

Anti-Tyrosyl tRNA synthetase antibody [EPR9927] (ab154819)

Overview

  • Product name
    Anti-Tyrosyl tRNA synthetase antibody [EPR9927]
    See all Tyrosyl tRNA synthetase primary antibodies
  • Description
    Rabbit monoclonal [EPR9927] to Tyrosyl tRNA synthetase
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, ICC/IFmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues within Human Tyrosyl tRNA synthetase (P54577).

  • Positive control
    • C6; PC12; Raji; HeLa and ECV 304 cell lysates; HeLa cells.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab154819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 59 kDa.
ICC/IF 1/250 - 1/500.
  • Application notes
    Is unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • Function
      Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
    • Involvement in disease
      Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
    • Sequence similarities
      Belongs to the class-I aminoacyl-tRNA synthetase family.
      Contains 1 tRNA-binding domain.
    • Cellular localization
      Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • CMTDIC antibody
      • SYYC_HUMAN antibody
      • Tyrosine tRNA ligase, cytoplasmic antibody
      • Tyrosine tRNA ligase 1, cytoplasmic antibody
      • Tyrosyl tRNA synthetase antibody
      • Tyrosyl--tRNA ligase antibody
      • Tyrosyl-tRNA synthetase, cytoplasmic antibody
      • TyrRS antibody
      • yars antibody
      • YRS antibody
      • YTS antibody
      see all

    Images

    • All lanes : Anti-Tyrosyl tRNA synthetase antibody [EPR9927] (ab154819) at 1/1000 dilution

      Lane 1 : C6 cell lysate
      Lane 2 : PC12 cell lysate
      Lane 3 : Raji cell lysate
      Lane 4 : HeLa cell lysate
      Lane 5 : ECV-304 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 59 kDa

    • Immunofluorescence analysis of HeLa cells, labeling Tyrosyl tRNA synthetase using ab154819 at 1/250 dilution.

    References

    ab154819 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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