Tyrphostin 1 (Tyrphostin A1), Inactive tyrphostin (ab145235)

Overview

  • Product name

    Tyrphostin 1 (Tyrphostin A1), Inactive tyrphostin
  • Description

    Inactive tyrphostin
  • Alternative names

    • Tyrphostin A1
  • Biological description

    Inactive tyrphostin. Negative control for tyrphostins such as AG 490 (ab120950). Inhibits CD40 signaling pathway. Reduces IL-12 production in macrophages. Blocks CD40L-induced translocation of NFκB to the nucleus. Shows antiallergic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    2826-26-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Davoodi-Semiromi A  et al. Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor. J Clin Immunol 32:1038-47 (2012). Read more (PubMed: 22661285) »
  • Banbury DN  et al. Tyrphostin A23 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex. J Biol Chem 278:12022-8 (2003). Read more (PubMed: 12556528) »
  • Du C  et al. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice. J Neuroimmunol 114:69-79 (2001). Read more (PubMed: 11240017) »

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