Overview

  • Product name

    Tyrphostin 25 (RG-50875), Competitive EGF receptor tyrosine kinase inhibitor
  • Description

    Competitive EGF receptor tyrosine kinase inhibitor
  • Biological description

    Cell-permeable and competitive inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 μM). Effects platelet-derived growth factor (PDGF) and insulin receptor tyrosine kinases. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    118409-58-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Partik G  et al. Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro. J Cancer Res Clin Oncol 125:379-88 (1999). Read more (PubMed: 10394957) »
  • Magga J  et al. Involvement of transcriptional and posttranscriptional mechanisms in cardiac overload-induced increase of B-type natriuretic peptide gene expression. Circ Res 81:694-702 (1997). Read more (PubMed: 9351443) »
  • Gazit A  et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32:2344-52 (1989). Read more (PubMed: 2552117) »

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