Product nameTyrphostin 47, EGFR tyrosine kinase inhibitor
DescriptionEGFR tyrosine kinase inhibitor
Biological descriptionEpidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC50 = 2.4 μM). Also inhibits platelet-derived growth factor (PDGF) receptor tyrosine kinase.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 75 mM and in ethanol to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
This product has been referenced in:
- Dvir A et al. The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers. J Cell Biol 113:857-65 (1991). Read more (PubMed: 1709168) »
- Gazit A et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32:2344-52 (1989). Read more (PubMed: 2552117) »
- Yaish P et al. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242:933-5 (1988). Read more (PubMed: 3263702) »