Overview

  • Product name

    Tyrphostin 9, PDGFR tyrosine kinase inhibitor
  • Description

    Selective PDGFR tyrosine kinase inhibitor
  • Biological description

    Selective inhibitor of platelet-derived growth factor (PDGF) receptor tyrosine kinase (IC50 = 1.2 μM). Also inhibits epidermal growth factor (EGF) receptor kinase (IC50 = 460 μM). Potent uncoupler of oxidative phosphorylation.
  • Purity

    > 99%
  • CAS Number

    10537-47-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Burger AM  et al. Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria. Cancer Res 55:2794-9 (1995). Read more (PubMed: 7796405) »
  • Levitzki A & Gilon C Tyrphostins as molecular tools and potential antiproliferative drugs. Trends Pharmacol Sci 12:171-4 (1991). Read more (PubMed: 1862529) »
  • Gazit A  et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32:2344-52 (1989). Read more (PubMed: 2552117) »

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