Overview

  • Product name

    Tyrphostin AG 957, p210 tyrosine kinase inhibitor
  • Description

    Potent, selective p210 tyrosine kinase inhibitor
  • Biological description

    Potent, selective p210 tyrosine kinase inhibitor (IC50 values are 1 and 7.1 μM at p210bcr-abl and p140c-abl respectively). Able to induce apoptosis and growth arrest by affecting the phosphorylation state of PI3K/Akt.
  • Purity

    > 99%
  • CAS Number

    140674-76-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoic acid methyl ester
  • Molecular weight

    273.29
  • Molecular formula

    C15H15NO4
  • PubChem identifier

    2064
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc2ccc(O)cc2CNc1ccc(cc1)C(=O)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Knijn A  et al. Metabolic alterations in K562 cells exposed to taxol and tyrphostin AG957: 1H NMR and biochemical studies. Cell Biol Int 29:890-7 (2005). Read more (PubMed: 16181795) »
  • Urbano A  et al. Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells. Biochem Pharmacol 63:689-92 (2002). Read more (PubMed: 11992636) »
  • Bhatia R  et al. Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors. Leukemia 12:1708-17 (1998). Read more (PubMed: 9823945) »
  • Anafi M  et al. Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins. J Biol Chem 267:4518-23 (1992). Read more (PubMed: 1537837) »

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