Overview

  • Product name

    U-69593, kappa1-opioid receptor agonist
  • Description

    Potent, selective κ1-opioid receptor agonist
  • Biological description

    Potent, selective κ1-opioid receptor agonist (EC50 = 80-109 nM). Active in vivo. Antinociceptive.
  • Purity

    > 99%
  • CAS Number

    96744-75-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-Methyl-N-[(5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide
  • Molecular weight

    356.10
  • Molecular formula

    C22H32N2O2
  • PubChem identifier

    105104
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C1CCC2(CCCO2)CC1N3CCCC3)C(=O)CC4=CC=CC=C4
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Escobar Adel P  et al. Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats. Neurochem Int 60:344-9 (2012). Read more (PubMed: 22306346) »
  • Ko MC  et al. Studies of micro-, kappa-, and delta-opioid receptor density and G protein activation in the cortex and thalamus of monkeys. J Pharmacol Exp Ther 306:179-86 (2003). Read more (PubMed: 12676881) »
  • Schenk S  et al. Effects of the kappa-opioid receptor agonist, U69593, on the development of sensitization and on the maintenance of cocaine self-administration. Neuropsychopharmacology 24:441-50 (2001). Read more (PubMed: 11182539) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141703.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up