Key features and details
- Standard phospholipase C (PLC) inhibitor
- CAS Number: 112648-68-7
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameU 73122, Standard phospholipase C (PLC) inhibitor
DescriptionStandard phospholipase C (PLC) inhibitor
Standard phospholipase C inhibitor (PLC) (IC50 = ~6 µM at PLC-β3). Shows a variety of biological activities including antiplatelet activation, Ca2+ signaling modulation and inhibition of 5-lipoxygenase activity. Active in vivo.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120998 has been referenced in 5 publications.
- Li H et al. Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies. J Extracell Vesicles 9:1812261 (2020). PubMed: 32944196
- Mizuno K et al. Role of Ca2+ transients at the node of the mouse embryo in breaking of left-right symmetry. Sci Adv 6:eaba1195 (2020). PubMed: 32743070
- Tsai CN et al. Serine 229 Balances the Hepatitis C Virus Nonstructural Protein NS5A between Hypo- and Hyperphosphorylated States. J Virol 93:N/A (2019). PubMed: 31511391
- Kárpáti A et al. Histamine elicits glutamate release from cultured astrocytes. J Pharmacol Sci N/A:N/A (2018). PubMed: 29858014
- Abdoul-Azize S et al. Improvement of dexamethasone sensitivity by chelation of intracellular Ca2+ in pediatric acute lymphoblastic leukemia cells through the prosurvival kinase ERK1/2 deactivation. Oncotarget 8:27339-27352 (2017). PubMed: 28423696