Overview

  • Product name

    U-75302, Leukotriene B4 BLT1 receptor antagonist
  • Description

    Selective leukotriene B4 BLT1 receptor antagonist
  • Biological description

    Selective leukotriene B4 BLT1 receptor antagonist (IC50 = 1.5 μM). Active in vitro and in vivo. Inhibits innate immune response and augments the leukocyte antiadesive effect of aspirin.
  • Purity

    > 99%
  • CAS Number

    119477-85-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Mazzetti L  et al. The ACh-induced contraction in rat aortas is mediated by the Cys Lt1 receptor via intracellular calcium mobilization in smooth muscle cells. Br J Pharmacol 138:707-15 (2003). Read more (PubMed: 12598425) »
  • Fiorucci S  et al. Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin. Br J Pharmacol 139:1351-9 (2003). Read more (PubMed: 12890715) »
  • Welbourn R  et al. Neutrophil adherence receptors (CD 18) in ischemia. Dissociation between quantitative cell surface expression and diapedesis mediated by leukotriene B4. J Immunol 145:1906-11 (1990). Read more (PubMed: 1975261) »

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