Overview

  • Product name

  • Description

    Rabbit polyclonal to U2AF1L4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human U2AF1L4 aa 1-202.
    Database link: Q8WU68

  • Positive control

    • IHC-P: Human testis tissue.
  • General notes

     This product was previously labelled as U2AF1L3

     

Properties

Applications

Our Abpromise guarantee covers the use of ab229886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site.
  • Tissue specificity

    Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes.
  • Sequence similarities

    Belongs to the splicing factor SR family.
    Contains 2 C3H1-type zinc fingers.
    Contains 1 RRM (RNA recognition motif) domain.
  • Domain

    The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events.
  • Cellular localization

    Nucleus. Nucleus speckle.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ35525 antibody
    • MGC33901 antibody
    • Splicing factor U2AF 26 kDa subunit antibody
    • U2 auxiliary factor 26 antibody
    • U2 small nuclear RNA auxiliary factor 1 like 3 antibody
    • U2 small nuclear RNA auxiliary factor 1 like 4 antibody
    • U2 small nuclear RNA auxiliary factor 1 like protein 3 antibody
    • U2 small nuclear RNA auxiliary factor 1 like protein 4 antibody
    • U2 small nuclear RNA auxiliary factor 1-like protein 3 antibody
    • U2 small nuclear RNA auxiliary factor 1-like protein 4 antibody
    • U2(RNU2) small nuclear RNA auxiliary factor 1 like 3 antibody
    • U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3 antibody
    • U2AF1 like protein 3 antibody
    • U2AF1 RS3 antibody
    • U2AF1-like protein 3 antibody
    • U2AF1L3V1 antibody
    • U2AF1L4 antibody
    • U2AF1RS3 antibody
    • U2af26 antibody
    • U2AF4_HUMAN antibody
    • U2RNU2 small nuclear RNA auxiliary factor 1 like 3 antibody
    • U2RNU2 small nuclear RNA auxiliary factor 1 like protein 3 antibody
    see all

Images

  • Paraffin-embedded human testis tissue stained for U2AF1L4 using ab229886 at 1/100 dilution in immunohistochemical analysis.

References

ab229886 has not yet been referenced specifically in any publications.

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