Key features and details
- Mouse polyclonal to UACA/Nucling
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-UACA/Nucling antibody
See all UACA/Nucling primary antibodies
DescriptionMouse polyclonal to UACA/Nucling
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Full length protein corresponding to Human UACA/Nucling aa 1-1416.
MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKV TSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTA GRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSI QLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQN RTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILT LLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLE IENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKS LLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQ MYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMR TFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALK DVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLK VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKL VEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGE LGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLE TVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTN LKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKI KDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL ANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKA TEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL IEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEI LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT KLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE VSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTI TELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDV QEALLQIIQMRQGLVC
Database link: NP_060473.2
- UACA/Nucling transfected 293T cell lysate.
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Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.4
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab169684 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 163 kDa.|
FunctionRegulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury.
Tissue specificityHighly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
Sequence similaritiesContains 6 ANK repeats.
Cellular localizationNucleus. Cytoplasm. Cytoplasm > cytoskeleton. Expressed diffusely in cytoplasm.
- Information by UniProt
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ab169684 has been referenced in 1 publication.
- Hwang S et al. Inhibitory Effect of Lycopene on Amyloid-ß-Induced Apoptosis in Neuronal Cells. Nutrients 9:N/A (2017). PubMed: 28813012