Anti-UACA/Nucling antibody [UACA/1222] (ab233956)

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Overview

  • Product name

    Anti-UACA/Nucling antibody [UACA/1222]
    See all UACA/Nucling primary antibodies

  • Description

    Mouse monoclonal [UACA/1222] to UACA/Nucling

  • Host species

    Mouse

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant fragment corresponding to Human UACA/Nucling.
    Database link: Q9BZF9

  • Positive control

    • WB: A549 cell lysate.

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: PBS, 0.05% BSA
  • Concentration information loading...

  • Purity

    Protein A/G purified

  • Purification notes

    Purified from bioreactor concentrate by Protein A/G.

  • Clonality

    Monoclonal

  • Clone number

    UACA/1222

  • Isotype

    IgG1

  • Light chain type

    kappa

  • Research areas

Applications

Our Abpromise guarantee covers the use of ab233956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 163 kDa.

Target

  • Function

    Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
    Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury.

  • Tissue specificity

    Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.

  • Sequence similarities

    Contains 6 ANK repeats.

  • Cellular localization

    Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Expressed diffusely in cytoplasm.
  • Information by UniProt

  • Database links

    • Alternative names

      • FLJ10128 antibody
      • KIAA1561 antibody
      • MGC141967 antibody
      • MGC141969 antibody
      • Nuclear membrane binding protein antibody
      • NUCLING antibody
      • UACA antibody
      • UACA_HUMAN antibody
      • Uveal autoantigen with coiled coil domains and ankyrin repeats antibody
      • Uveal autoantigen with coiled-coil domains and ankyrin repeats antibody
      see all

    Images

    • Western blot - Anti-UACA/Nucling antibody [UACA/1222] (ab233956)
      Western blot - Anti-UACA/Nucling antibody [UACA/1222] (ab233956)
      Anti-UACA/Nucling antibody [UACA/1222] (ab233956) at 1 µg/ml + A549 (Human lung carcinoma cell line) cell lysate

      Predicted band size: 163 kDa

    References

    ab233956 has not yet been referenced specifically in any publications.

    Publishing research using ab233956? Please let us know so that we can cite the reference in this datasheet.

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