Overview

  • Product name
    Anti-UBE2D2 antibody [EPR11031(B)]
    See all UBE2D2 primary antibodies
  • Description
    Rabbit monoclonal [EPR11031(B)] to UBE2D2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: Flow Cyt,ICC/IF or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human UBE2D2 (UniProt: P62837).

  • Positive control
    • MCF7, 293T, HeLa and Human fetal brain lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab155088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 16 kDa.
IP 1/10 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • Target

    • Function
      Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
    • Pathway
      Protein modification; protein ubiquitination.
    • Sequence similarities
      Belongs to the ubiquitin-conjugating enzyme family.
    • Information by UniProt
    • Database links
    • Alternative names
      • E2(17)KB2 antibody
      • OTTHUMP00000223475 antibody
      • OTTHUMP00000223476 antibody
      • OTTHUMP00000223477 antibody
      • OTTHUMP00000223478 antibody
      • OTTHUMP00000224375 antibody
      • PUBC 1 antibody
      • PUBC1 antibody
      • UB2D2_HUMAN antibody
      • UBC 4 antibody
      • UBC 4/5 antibody
      • UBC4 antibody
      • UBC4/5 antibody
      • UBC4/5 homolog yeast antibody
      • UBCH 5B antibody
      • UBCH5B antibody
      • UBE2D2 antibody
      • Ubiquitin carrier protein antibody
      • Ubiquitin carrier protein D2 antibody
      • Ubiquitin conjugating enzyme E2 17 kDa 2 antibody
      • Ubiquitin conjugating enzyme E2 D2 antibody
      • Ubiquitin conjugating enzyme E2D 2 (homologous to yeast UBC4/5) antibody
      • Ubiquitin conjugating enzyme E2D 2 (UBC4/5 homolog yeast) antibody
      • Ubiquitin conjugating enzyme E2D 2 antibody
      • Ubiquitin protein ligase D2 antibody
      • Ubiquitin-conjugating enzyme E2 D2 antibody
      • Ubiquitin-conjugating enzyme E2(17)KB 2 antibody
      • Ubiquitin-conjugating enzyme E2-17 kDa 2 antibody
      • Ubiquitin-protein ligase D2 antibody
      see all

    Images

    • All lanes : Anti-UBE2D2 antibody [EPR11031(B)] (ab155088) at 1/1000 dilution

      Lane 1 : MCF7 cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : 293T cell lysate
      Lane 4 : Human fetal brain lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 16 kDa

    References

    This product has been referenced in:
    • Shi Y  et al. Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity. Nat Commun 8:15138 (2017). WB ; Human . Read more (PubMed: 28469175) »
    • Garzia A  et al. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nat Commun 8:16056 (2017). Read more (PubMed: 28685749) »
    See all 3 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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