Overview

  • Product name

    Anti-UBE2V1 antibody [EPR4735(2)]
    See all UBE2V1 primary antibodies
  • Description

    Rabbit monoclonal [EPR4735(2)] to UBE2V1
  • Host species

    Rabbit
  • Specificity

    The immunogen used for this antibody shares 93% identity with Ube2v2. Cross-reactivity with this protein has not been confirmed experimentally.
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human UBE2V1 (UniProt: Q13404).

  • Positive control

    • Human fetal brain, HT29, Human fetal kidney and BxPC3 lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab151725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 16 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function

      Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
    • Tissue specificity

      Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.
    • Sequence similarities

      Belongs to the ubiquitin-conjugating enzyme family.
    • Cellular localization

      Nucleus. Excluded from the nucleolus.
    • Information by UniProt
    • Database links

    • Alternative names

      • CIR1 antibody
      • CROC-1 antibody
      • CROC1 antibody
      • CROC1A antibody
      • TRAF6-regulated IKK activator 1 beta Uev1A antibody
      • UB2V1_HUMAN antibody
      • UBE2V 1 antibody
      • UBE2V antibody
      • UBE2V1 antibody
      • Ubiquitin conjugating enzyme E2 variant 1 antibody
      • Ubiquitin-conjugating enzyme E2 variant 1 antibody
      • UEV-1 antibody
      • UEV1 antibody
      see all

    Images

    • All lanes : Anti-UBE2V1 antibody [EPR4735(2)] (ab151725) at 1/1000 dilution

      Lane 1 : Human fetal brain lysate
      Lane 2 : HT29 cell lysate
      Lane 3 : Human fetal kidney lysate
      Lane 4 : BxPC3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 16 kDa

    References

    This product has been referenced in:

    • Shen T  et al. Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy. J Hematol Oncol 11:95 (2018). Read more (PubMed: 30016968) »
    See 1 Publication for this product

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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