Key features and details
- Rabbit polyclonal to UBIAD1 - C-terminal
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-UBIAD1 antibody - C-terminal
DescriptionRabbit polyclonal to UBIAD1 - C-terminal
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human UBIAD1 (C terminal). Peptide corresponds to 15 amino acids near the carboxy terminus (NP_037451.1).
Database link: Q9Y5Z9
- Mouse liver tissue and tissue lysate.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab191691 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 5 - 20 µg/ml.|
|WB||Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 37 kDa).|
FunctionPrenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas. Mediates the conversion of phylloquinone (PK) into menaquinone-4 (MK-4), probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4.
Tissue specificityUbiquitously expressed.
PathwayCofactor biosynthesis; menaquinone biosynthesis.
Involvement in diseaseDefects in UBIAD1 are the cause of crystalline corneal dystrophy of Schnyder (SCCD) [MIM:121800]. SCCD is a rare autosomal dominant disease characterized by progressive corneal opacification resulting from abnormal deposition of cholesterol and phospholipids.
Sequence similaritiesBelongs to the ubiA prenyltransferase family.
Cellular localizationEndoplasmic reticulum membrane. Cytoplasm. Nucleus. Mitochondrion.
- Information by UniProt
- RP4-796F18.1 antibody
- SCCD antibody
- TERE 1 antibody
All lanes : Anti-UBIAD1 antibody - C-terminal (ab191691) at 1 µg/ml
Lane 1 : mouse liver tissue lysate with out blocking peptide
Lane 2 : mouse liver tissue lysate with blocking peptide
Lysates/proteins at 15 µg per lane.
Developed using the ECL technique.
Predicted band size: 37 kDa
Observed band size: 45 kDa why is the actual band size different from the predicted?
Immunohistochemical staining of mouse liver tissue, labeling UBIAD1 using ab191691 at 20 μg/mL.
Immunohistochemical analysis of paraffin-embedded mouse liver tissue, labeling UBIAD1 using ab191691 at 5 μg/mL.
ab191691 has been referenced in 1 publication.
- Yan B et al. Depletion of ubiA prenyltransferase domain containing 1 expression promotes angiotensin II-induced hypertrophic response in AC16 human myocardial cells via modulating the expression levels of coenzyme Q10 and endothelial nitric oxide synthase. Mol Med Rep 16:6910-6915 (2017). PubMed: 28901410