Anti-Ubiquitin antibody [Ubi-1] (ab7254)

Mouse monoclonal Ubiquitin antibody [Ubi-1]. Validated in WB, ELISA, IHC, ICC/IF and tested in Mouse, Rat, Chicken, Cow, Human, Arabidopsis thaliana, Caenorhabditis elegans and more.

Publishing research using ab7254? Please let us know so that we can cite the reference in this datasheet.

ab7254 has been referenced in 43 publications.

  • Martínez-Puente DH  et al. Targeting HPV-16 antigens to the endoplasmic reticulum induces an endoplasmic reticulum stress response. Cell Stress Chaperones 24:149-158 (2019). PubMed: 30604352
  • Ren CC  et al. Effects of shRNA-mediated silencing of PSMA7 on cell proliferation and vascular endothelial growth factor expression via the ubiquitin-proteasome pathway in cervical cancer. J Cell Physiol 234:5851-5862 (2019). PubMed: 29247526
  • Sun J  et al. The ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43. J Biol Chem 293:8275-8284 (2018). PubMed: 29626091
  • Henrich MT  et al. A53T-a-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta Neuropathol Commun 6:39 (2018). PubMed: 29747690
  • Chiang ACA  et al. Combination anti-Aß treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. J Exp Med 215:1349-1364 (2018). PubMed: 29626114
  • Augé E  et al. Exploring the elusive composition of corpora amylacea of human brain. Sci Rep 8:13525 (2018). PubMed: 30202002
  • Takanashi M  et al. Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations. Acta Neuropathol Commun 6:105 (2018). PubMed: 30333048
  • Bromfield EG  et al. Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse. Mol Hum Reprod 23:91-105 (2017). PubMed: 27932549
  • Wang J  et al. Tissue-Specific Ubiquitination by IPA1 INTERACTING PROTEIN1 Modulates IPA1 Protein Levels to Regulate Plant Architecture in Rice. Plant Cell 29:697-707 (2017). PubMed: 28298520
  • Tikhmyanova N  et al. Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation. PLoS Pathog 13:e1006517 (2017). PubMed: 28715492
  • Jiang R  et al. The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion. Nat Commun 8:15129 (2017). WB, IP . PubMed: 28541302
  • Kaneko Y  et al. Extracellular HMGB1 Modulates Glutamate Metabolism Associated with Kainic Acid-Induced Epilepsy-Like Hyperactivity in Primary Rat Neural Cells. Cell Physiol Biochem 41:947-959 (2017). PubMed: 28222432
  • Chen M  et al. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. Elife 6:N/A (2017). WB ; Mouse . PubMed: 28054918
  • Jiang YF  et al. Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging. Sci Rep 7:45474 (2017). PubMed: 28358017
  • Luo C  et al. PARAQUAT TOLERANCE3 Is an E3 Ligase That Switches off Activated Oxidative Response by Targeting Histone-Modifying PROTEIN METHYLTRANSFERASE4b. PLoS Genet 12:e1006332 (2016). WB . PubMed: 27676073
  • Qu Y  et al. Axitinib blocks Wnt/ß-catenin signaling and directs asymmetric cell division in cancer. Proc Natl Acad Sci U S A 113:9339-44 (2016). WB . PubMed: 27482107
  • Yu Z  et al. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. Elife 5:N/A (2016). PubMed: 27063938
  • Li Q  et al. Temporal Profiles of Stress Protein Inductions after Focal Transient Ischemia in Mice Brain. J Stroke Cerebrovasc Dis 25:2344-51 (2016). PubMed: 27318648
  • Kim DK  et al. Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function. Autophagy 12:1849-1863 (2016). PubMed: 27485532
  • Schumacher FR  et al. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol Med 7:1285-306 (2015). PubMed: 26286618
  • Farrawell NE  et al. Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions. Sci Rep 5:13416 (2015). PubMed: 26293199
  • Bounedjah O  et al. Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules. Nucleic Acids Res 42:8678-91 (2014). PubMed: 25013173
  • Liu C  et al. Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open 3:861-70 (2014). WB . PubMed: 25190059
  • Pla A  et al. TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain. Cell Death Dis 5:e1066 (2014). WB, ICC/IF ; Mouse . PubMed: 24556681
  • Gatliff J  et al. TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy 10:2279-96 (2014). PubMed: 25470454
  • Andersson V  et al. Enhancing protein disaggregation restores proteasome activity in aged cells. Aging (Albany NY) 5:802-12 (2013). WB . PubMed: 24243762
  • Nunes P  et al. Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Autophagy 9:550-67 (2013). PubMed: 23380587
  • Jin X  et al. A potential role for CHH DNA methylation in cotton fiber growth patterns. PLoS One 8:e60547 (2013). WB . PubMed: 23593241
  • Khoronenkova SV & Dianov GL USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. Nucleic Acids Res 41:1750-6 (2013). WB . PubMed: 23275561
  • Zhang D  et al. Acetylation regulates Jun protein turnover in Drosophila. Biochim Biophys Acta 1829:1218-1224 (2013). PubMed: 23891849
  • Ye S  et al. The E3 Ubiquitin Ligase Neuregulin Receptor Degradation Protein 1 (Nrdp1) Promotes M2 Macrophage Polarization by Ubiquitinating and Activating Transcription Factor CCAAT/Enhancer-binding Protein ß (C/EBPß). J Biol Chem 287:26740-8 (2012). WB . PubMed: 22707723
  • Castiel A  et al. The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr. J Cell Sci 124:532-9 (2011). WB ; Mouse . PubMed: 21245198
  • Ohmi K  et al. Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. PLoS One 6:e27461 (2011). IHC-Fr ; Mouse . PubMed: 22096577
  • Hasegawa M  et al. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J 27:373-83 (2008). WB ; Human . PubMed: 18079694
  • Tannous P  et al. Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation 117:3070-8 (2008). PubMed: 18541737
  • Tannous P  et al. Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A 105:9745-50 (2008). IHC-P . PubMed: 18621691
  • Kuo CT  et al. Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc Natl Acad Sci U S A 102:15230-5 (2005). ICC/IF . PubMed: 16210248
  • He CZ & Hays AP Expression of peripherin in ubiquinated inclusions of amyotrophic lateral sclerosis. J Neurol Sci 217:47-54 (2004). PubMed: 14675609
  • Boutajangout A  et al. Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1. Neurobiol Dis 15:47-60 (2004). PubMed: 14751770
  • Wang DS  et al. Contribution of changes in ubiquitin and myelin basic protein to age-related cognitive decline. Neurosci Res 48:93-100 (2004). PubMed: 14687885
  • Woods YL  et al. p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase. J Biol Chem 279:50157-66 (2004). PubMed: 15355988
  • Lichtenfels R  et al. Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses. Biochim Biophys Acta 1646:21-31 (2003). PubMed: 12637008
  • Ungureanu D  et al. Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol 22:3316-26 (2002). PubMed: 11971965

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up