Anti-CIP75 antibody (ab106443)
Key features and details
- Rabbit polyclonal to CIP75
- Suitable for: IHC-P, WB
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-CIP75 antibody
See all CIP75 primary antibodies -
Description
Rabbit polyclonal to CIP75 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Synthetic peptide corresponding to Human CIP75 (N terminal).
Database link: Q9NRR5 -
Positive control
- 3T3 cell lysate, Mouse kidney tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106443 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
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WB | (1) |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 64 kDa.
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Notes |
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IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol. |
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 64 kDa. |
Target
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Tissue specificity
Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver. -
Sequence similarities
Contains 1 UBA domain.
Contains 1 ubiquitin-like domain. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Nucleus. Cytoplasm. Endoplasmic reticulum. May associate with the endoplasmic reticulum. - Information by UniProt
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Database links
- Entrez Gene: 94232 Mouse
- SwissProt: Q99NB8 Mouse
- Unigene: 303059 Mouse
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Alternative names
- 28S ribosomal protein S7 antibody
- A1U antibody
- A1Up antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab106443 has been referenced in 4 publications.
- Liu F et al. UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma. Mol Oncol 15:3738-3752 (2021). PubMed: 34245648
- Sentürk M et al. Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Nat Cell Biol 21:384-396 (2019). PubMed: 30804504
- Itakura E et al. Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation. Mol Cell 63:21-33 (2016). WB ; Human . PubMed: 27345149
- Coffey RT et al. Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. J Biol Chem 291:5221-33 (2016). PubMed: 26740621