Overview

  • Product name

    UC2288, p21 inhibitor
  • Description

    Novel, selective, cell permeable p21 inhibitor
  • Alternative names

    • p21/Cip1/CKI/Waf1 Inhibitor
    • t-CTTU
    • trans-1-(4-Chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea
    • UC-2288
  • Biological description

    Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI50 = ~ 10 µM against NCI60 cell lines).

  • Purity

    > 98%
  • CAS Number

    1394011-91-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((1r,4r)-4-(5-(trifluoromethyl)pyridin-2-yloxy)cyclohexyl)urea
  • Molecular weight

    481.82
  • Molecular formula

    C20H18ClF6N3O2
  • Storage instructions

    Shipped at Room Temperature. Store at +4°C. Store In the Dark.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    FC(F)(F)c1cc(ccc1Cl)NC(=O)N[C@H]2CC[C@@H](CC2)Oc3ccc(cn3)C(F)(F)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Gupta R  et al. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc Natl Acad Sci U S A 111:E3062-71 (2014). Read more (PubMed: 25024194) »
  • Liu R  et al. Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer. Future Med Chem 5:991-4 (2013). Read more (PubMed: 23734682) »
  • Wettersten HI  et al. A novel p21 attenuator which is structurally related to sorafenib. Cancer Biol Ther 14:278-85 (2013). Read more (PubMed: 23298903) »

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