Overview

  • Product name

    UCPH-101, Selective EAAT1 inhibitor
  • Description

    Selective EAAT1 inhibitor
  • Biological description

    Selective inhibitor of EAAT1 (IC50 = 0.67 μM). Displays >400-fold selectivity over EAAT2 and EAAT3.

    Blood-brain barrier permeable analog UCPH-102 also available (ab146404).
  • Purity

    > 98%
  • CAS Number

    1118460-77-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Erichsen MN  et al. Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). J Med Chem 53:7180-91 (2010). Read more (PubMed: 20857912) »
  • Jensen AA  et al. Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1. J Med Chem 52:912-5 (2009). Read more (PubMed: 19161278) »
See all 5 Publications for this product

Customer reviews and Q&As

Answer

Thank you for your calls earlier this week and for your patience while I have been in touch with the Abcam Biochemicals lab regarding your enquiry.

I have heard from my colleagues:

Unfortunately this compound has not be tried in ACSF. However, we do know that UCPH-101 can be diluted to 100 uM (using heatingin water bath and sonicating) in Hank's buffered Saline Solution supplemented with 20 mM HEPES (pH 7.4) and also in Krebs buffer ( [140 mM NaCl/4.7 mM KCl/2.5 mM CaCl2/1.2 mM MgCl2/11 mM HEPES/10 mM D-Glucose, pH 7.4].). It may be helpful to try gently heating the solution.

After a literature search, we could not find any further information about this compound's solubility in ACSF.

I am sorry that I don't have any more information, but if there is anything else that we can do for you please let me know, and I'll be happy to help.

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