Product nameAnti-UFD1L antibody [5e2]
See all UFD1L primary antibodies
DescriptionMouse monoclonal [5e2] to UFD1L
Tested applicationsSuitable for: WB, IP, ELISA, ICC/IFmore details
Species reactivityReacts with: Mouse, Human, Xenopus laevis
Recombinant full length protein (Mouse) expressed in E coli.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferConstituent: PBS
PBS (sterile and filtered)
Concentration information loading...
Our Abpromise guarantee covers the use of ab52094 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionEssential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
Tissue specificityFound in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
PathwayProtein degradation; proteasomal ubiquitin-dependent pathway.
Sequence similaritiesBelongs to the UFD1 family.
Cellular localizationNucleus. Cytoplasm > cytosol.
- Information by UniProt
- UB fusion protein 1 antibody
- Ubiquitin fusion degradation 1 like (yeast) antibody
- Ubiquitin fusion degradation 1 like antibody
ab52094 has not yet been referenced specifically in any publications.