Overview

  • Product name

    Anti-UGT1A4 antibody
  • Description

    Rabbit polyclonal to UGT1A4
  • Host species

    Rabbit
  • Specificity

    Ddetects endogenous levels of UGT1A4 protein.
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human UGT1A4.
    Database link: P22310

Properties

Applications

Our Abpromise guarantee covers the use of ab192424 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 60 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • Function

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.
  • Tissue specificity

    Expressed in liver. Not expressed in skin or kidney.
  • Involvement in disease

    Defects in UGT1A4 are the cause of Gilbert syndrome (GILBS) [MIM:143500]. Gilbert syndrome occurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague nonspecific complaints.
    Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 1 (CN1) [MIM:218800]. CN1 patients have severe hyperbilirubinemia and usually die of kernicterus (bilirubin accumulation in the basal ganglia and brainstem nuclei) within the first year of life. CN1 inheritance is autosomal recessive.
    Defects in UGT1A4 are the cause of Crigler-Najjar syndrome type 2 (CN2) [MIM:606785]. CN2 patients have less severe hyperbilirubinemia and usually survive into adulthood without neurologic damage. Phenobarbital, which induces the partially deficient glucuronyl transferase, can diminish the jaundice. CN2 inheritance is autosomal dominant.
  • Sequence similarities

    Belongs to the UDP-glycosyltransferase family.
  • Cellular localization

    Microsome. Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Bilirubin UDP glucuronosyltransferase isozyme 2 antibody
    • Bilirubin-specific UDPGT isozyme 2 antibody
    • HUG-BR2 antibody
    • UD14_HUMAN antibody
    • UDP glucuronosyltransferase 1 family polypeptide A4 antibody
    • UDP glycosyltransferase 1 family polypeptide A4 antibody
    • UDP-glucuronosyltransferase 1-4 antibody
    • UDP-glucuronosyltransferase 1-D antibody
    • UDP-glucuronosyltransferase 1A4 antibody
    • UDPGT 1-4 antibody
    • UDPGT antibody
    • UGT-1D antibody
    • UGT1*4 antibody
    • UGT1-04 antibody
    • UGT1.4 antibody
    • UGT1A4 antibody
    • UGT1D antibody
    see all

References

ab192424 has not yet been referenced specifically in any publications.

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