Overview

  • Product name
    Anti-UGT2B4 antibody [EPR11677]
  • Description
    Rabbit monoclonal [EPR11677] to UGT2B4
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: FM,ICC/IF or IHC-P
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human UGT2B4 aa 500 to the C-terminus. The exact sequence is proprietary.
    Database link: P06133

  • Positive control
    • Human Fetal liver, HepG2, LNCap lysates. HepG2 cells.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab173580 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/100000. Predicted molecular weight: 61 kDa.
IP 1/10 - 1/100.
  • Application notes
    Is unsuitable for FM,ICC/IF or IHC-P.
  • Target

    • Relevance
      The UDP-Glucuronosyltransferases (UGT) comprise a family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups. They have been subdivided into two families, UGT1 and UGT2, based on the evolutionary divergence of their genes. The enzymes of the UGT1A family play an important role in the metabolism of dietary constituents, phenols, and therapeutic drugs, and also the glucuronidation of bilirubin and iodothyronines. The enzymes of the UGT2B family are involved in the metabolism of bile acids, phenol derivatives, catecholestrogens and steroids. Although it is widely recognized that the liver is the major site of glucuronidation, it is now clear that UGT enzymes are also found in extra-hepatic tissues.
    • Cellular localization
      Microsome
    • Database links
    • Alternative names
      • EC 2.4.1.17 antibody
      • HLUG25 antibody
      • Hyodeoxycholic acid antibody
      • Hyodeoxycholic acid specific UDPGT antibody
      • UDP glucuronosyltransferase 2 family polypeptide B4 antibody
      • UDP glucuronosyltransferase 2B4 antibody
      • UDP glucuronosyltransferase 2B4 precursor antibody
      • UDP glucuronyltransferase family 2 beta 4 antibody
      • UDP glycosyltransferase 2 family polypeptide B4 antibody
      • UDP glycosyltransferase antibody
      • UDPGT antibody
      • UDPGT 2B4 antibody
      • UDPGT2B4 antibody
      • UDPGTh 1 antibody
      • UDPGTh1 antibody
      • UGT2B11 antibody
      • UGT2B4 antibody
      see all

    Images

    • Western blot analysis on immunoprecipitation pellet from (1) fetal liver lysate or (2) 1X PBS (negative control) using ab173580 at 1/10 dilution immunoprecipitating UGT2B4, and HRP-conjugated anti-rabbit IgG preferentially detecting the non-reduced form of rabbit IgG.

    • All lanes : Anti-UGT2B4 antibody [EPR11677] (ab173580) at 1/1000 dilution

      Lane 1 : Human fetal liver cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : LNCap cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 61 kDa

    References

    This product has been referenced in:
    • Chen X  et al. SPIN1, negatively regulated by miR-148/152, enhances Adriamycin resistance via upregulating drug metabolizing enzymes and transporter in breast cancer. J Exp Clin Cancer Res 37:100 (2018). WB . Read more (PubMed: 29743122) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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