UK-1, Topoisomerase II (Topo II) inhibitor (ab144380)

Overview

  • Product name

    UK-1, Topoisomerase II (Topo II) inhibitor
  • Description

    Topoisomerase II (Topo II) inhibitor
  • Alternative names

    • [2,4'-Bibenzoxazole]-4-carboxylicacid, 2'-(2-hydroxyphenyl)-, methyl ester
  • Biological description

    Topoisomerase II (Topo II) inhibitor. Antibacterial, antifungal and anticancer compound.
  • Purity

    > 98%
  • CAS Number

    151271-53-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2'-(2-Hydroxyphenyl)-(2,4'-bibenzoxazole)-4-carboxylic acid methyl ester
  • Molecular weight

    386.36
  • Molecular formula

    C22H14N2O5
  • PubChem identifier

    57348732
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(OC)c1cccc2oc(nc12)c3cccc4oc(nc34)c5ccccc5O
  • Source

    Streptomyces sp.

References

This product has been referenced in:

  • Wang BB  et al. Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs. Bioorg Med Chem Lett 14:3221-6 (2004). Read more (PubMed: 15149679) »
  • Kumar D  et al. Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1. Bioorg Med Chem 10:3997-4004 (2002). Read more (PubMed: 12413851) »
  • Ueki M & Taniguchi M UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. III. Antibacterial action of demethyl UK-1. J Antibiot (Tokyo) 50:788-90 (1997). Read more (PubMed: 9360628) »

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