• Product name

  • Description

    Mouse polyclonal to ULBP2
  • Host species

  • Tested applications

    Suitable for: WB, Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length protein corresponding to Human ULBP2 aa 1-246.
    Database link: Q9BZM5

  • Positive control

    • Human ovary cancer tissue lysate. Cell lysate from transfected 293T cells.


  • Form

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab88645 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa.
Flow Cyt Use at an assay dependent concentration.

ab37355 - Mouse polyclonal IgG, is suitable for use as an isotype control with this antibody.



  • Function

    Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
  • Tissue specificity

    Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
  • Sequence similarities

    Belongs to the MHC class I family.
  • Cellular localization

    Cell membrane. Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • ALCAN alpha antibody
    • ALCAN-alpha antibody
    • N2DL 2 antibody
    • N2DL-2 antibody
    • N2DL2 antibody
    • N2DL2_HUMAN antibody
    • NKG2D ligand 2 antibody
    • NKG2D ligand 2 precursor antibody
    • NKG2DL2 antibody
    • RAET1H antibody
    • Retinoic acid early transcript 1 H antibody
    • Retinoic acid early transcript 1H antibody
    • UL16 binding protein 2 antibody
    • UL16-binding protein 2 antibody
    • ULBP2 antibody
    see all


  • ab88645 detecting ULBP2 in ULBP2-expressing 293 cells (Green) compared with negative control 293 cells (Black) by flow cytometry.
  • Anti-ULBP2 antibody (ab88645) at 1 µg/ml + Human ovary cancer tissue lysate at 50 µg

    Predicted band size: 27 kDa
    Observed band size: ~35 kDa
    why is the actual band size different from the predicted?

  • All lanes : Anti-ULBP2 antibody (ab88645) at 1 µg/ml

    Lane 1 : cell lysate from ULBP2 transfected 293T cells
    Lane 2 : cell lysate from non transfected 293T cells

    Lysates/proteins at 25 µg per lane.

    Predicted band size: 27 kDa
    Observed band size: ~29 kDa why is the actual band size different from the predicted?
    Additional bands at: ~27 kDa, ~33 kDa. We are unsure as to the identity of these extra bands.


This product has been referenced in:

  • Dudek-Peric AM  et al. Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin. Cancer Res 75:1603-14 (2015). WB ; Human . Read more (PubMed: 25762540) »
See 1 Publication for this product

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