Recombinant
RabMAb

Anti-ULBP2 antibody [EPR4016(2)] (ab173286)

Overview

  • Product name
    Anti-ULBP2 antibody [EPR4016(2)]
    See all ULBP2 primary antibodies
  • Description
    Rabbit monoclonal [EPR4016(2)] to ULBP2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human ULBP2 aa 1-100. The exact sequence is proprietary.
    Database link: Q9BZM5

  • Positive control
    • ULBP2 over-expressed lysate.
  • General notes

    This antibody was developed as part of a collaboration between Epitomics and Hugh Reyburn at the Centro Nacional de Biotechnologia, Madrid.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
  • Purity
    Tissue culture supernatant
  • Clonality
    Monoclonal
  • Clone number
    EPR4016(2)
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab173286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Predicted molecular weight: 27 kDa.
  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function
      Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
    • Tissue specificity
      Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
    • Sequence similarities
      Belongs to the MHC class I family.
    • Cellular localization
      Cell membrane. Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • ALCAN alpha antibody
      • ALCAN-alpha antibody
      • N2DL 2 antibody
      • N2DL-2 antibody
      • N2DL2 antibody
      • N2DL2_HUMAN antibody
      • NKG2D ligand 2 antibody
      • NKG2D ligand 2 precursor antibody
      • NKG2DL2 antibody
      • RAET1H antibody
      • Retinoic acid early transcript 1 H antibody
      • Retinoic acid early transcript 1H antibody
      • UL16 binding protein 2 antibody
      • UL16-binding protein 2 antibody
      • ULBP2 antibody
      see all

    Images

    • Anti-ULBP2 antibody [EPR4016(2)] (ab173286) at 1/10000 dilution + ULBP2 over-expressed lysate at 10 µg

      Predicted band size: 27 kDa

    References

    ab173286 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab173286.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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