• Product name
  • Description
    Sheep polyclonal to UMOD
  • Host species
  • Tested applications
    Suitable for: Double Immunodiffusion, RID, Immunoelectrophoresismore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein corresponding to UMOD. Human UMOD purified from human urine. Greater than 95% purity by SDS-PAGE.

  • General notes

    Previously labelled as Uromucoid. 


  • Form
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.40
    Preservative: 0.1% Sodium azide
    Constituents: 0.1% EACA, 0.01% Benzamidine, 0.0292% EDTA
  • Concentration information loading...
  • Purity
    IgG fraction
  • Purification notes
    Antiserum is prepared by immunisation of sheep with Human UMOD and, if necessary, adsorbed to monospecificity by use of solid-phase adsorbents. An immunoglobulin fraction is then produced. The titre is adjusted so that inter-batch variation is within 10%. The product is 0.2µm filtered.
  • Clonality
  • Isotype
  • Light chain type
  • Research areas


Our Abpromise guarantee covers the use of ab9029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Double Immunodiffusion
Rocket Immunoelectrophoresis
  • Application notes
    RID and Rocket IEP : 10µL antiserum/cm² in gel vs 5µL uromucoid 50mg/L, NT – 1/5
    Double Diffusion : 10µL antiserum vs 3µL uromucoid 50mg/L
    IEP : 100µL antiserum vs 5µL uromucoid 50mg/L

    Optimal dilutions should be determined by the individual laboratory
    The use of 3% PEG 6000 with 1.2%agarose in a suitable buffer (such as TBE or Tris-barbital pH >8.2) is recommended.
    Suitability for use in enzyme-linked immunosorbentassays and Western blot has not been assessed but use in such assays should not necessarily beexcluded.
  • Target

    • Function
      Not known. May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
    • Tissue specificity
      Synthesized by kidney. Most abundant protein in normal human urine.
    • Involvement in disease
      Defects in UMOD are the cause of familial juvenile hyperuricemic nephropathy type 1 (HNFJ1) [MIM:162000]. HNFJ1 is a renal disease characterized by juvenil onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.
      Defects in UMOD are the cause of medullary cystic kidney disease type 2 (MCKD2) [MIM:603860]. MCKD2 is a form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade.
      Defects in UMOD are the cause of glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) [MIM:609886]. GCKDHI is a renal disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability.
    • Sequence similarities
      Contains 3 EGF-like domains.
      Contains 1 ZP domain.
    • Cellular localization
      Cell membrane. Secreted. Secreted after cleavage in the urine.
    • Information by UniProt
    • Database links
    • Alternative names
      • ADMCKD2 antibody
      • FJHN antibody
      • HNFJ antibody
      • HNFJ1 antibody
      • MCKD2 antibody
      • medullary cystic kidney disease 2 (autosomal dominant) antibody
      • Tamm Horsfall glycoprotein antibody
      • Tamm Horsfall urinary glycoprotein antibody
      • Tamm-Horsfall urinary glycoprotein antibody
      • THGP antibody
      • THP antibody
      • Umod antibody
      • Urehd1 antibody
      • urehr4 antibody
      • UROM_HUMAN antibody
      • uromodulin (uromucoid, Tamm-Horsfall glycoprotein) antibody
      • Uromodulin antibody
      • Uromodulin, secreted form antibody
      • Uromucoid antibody
      see all


    This product has been referenced in:
    • Trudu M  et al. Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations. Sci Rep 7:7383 (2017). Read more (PubMed: 28785050) »
    See 1 Publication for this product

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