Overview

  • Product name

    UNC0638, G9 and GLP histone methyltransferase inhibitor
  • Description

    Potent, selective and reversible G9 and GLP histone methyltransferase inhibitor
  • Biological description

    Potent, selective and reversible G9 and GLP histone methyl transferase inhibitor (IC50 values are 15 and 19 nM respectively). Maintains HSC multipotency in vitro. Cell-permeable.
  • Purity

    > 98%
  • CAS Number

    1255580-76-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Chen X  et al. G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment. Genes Dev 26:2499-511 (2012). Read more (PubMed: 23105005) »
  • Vedadi M  et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol 7:566-74 (2011). Read more (PubMed: 21743462) »
  • Liu F  et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem 54:6139-50 (2011). Read more (PubMed: 21780790) »

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