Key features and details
- Rabbit polyclonal to UNC13B
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-UNC13B antibody
See all UNC13B primary antibodies
DescriptionRabbit polyclonal to UNC13B
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Zebrafish
Recombinant protein fragment corresponding to a region within amino acids 462 and 719 of Human UNC13B (NP_006368)
- 293T and HeLa cells
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab97664 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 181 kDa.|
FunctionPlays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
Tissue specificityExpressed in kidney cortical epithelial cells and brain.
Sequence similaritiesBelongs to the unc-13 family.
Contains 3 C2 domains.
Contains 1 MHD1 (MUNC13 homology domain 1) domain.
Contains 1 MHD2 (MUNC13 homology domain 2) domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
DomainThe C2 domains are not involved in calcium-dependent phospholipid binding.
Cellular localizationCytoplasm. Membrane. Cell membrane. Cell junction > synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.
- Information by UniProt
- hmunc13 antibody
- MGC133279 antibody
- MGC133280 antibody
ab97664 has not yet been referenced specifically in any publications.