Overview

  • Product name
    UNC1999, EZH2 methyltransferase inhibitor
  • Description
    Potent, selective cell-permeable EZH2 methyltransferase inhibitor
  • Biological description
    Potent, selective cell-permeable EZH2 methyltransferase inhibitor (IC50 = 2 nM). Inhibits H3K27 methylation (IC50 = 124 nM, MCF10A cells). Competitive with the cofactor SAM, and non-competitive with the peptide substrate. Orally bioavailable.
  • Purity
    > 98%
  • CAS Number
    1431612-23-5
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Xu B  et al. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood 125:346-57 (2015). Read more (PubMed: 25395428) »
  • Katona BW  et al. EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells. Cancer Biol Ther 15:1677-87 (2014). Read more (PubMed: 25535899) »
  • Konze KD  et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol 8:1324-34 (2013). Read more (PubMed: 23614352) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146152.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up