• Product name
  • Description
    Rabbit polyclonal to UNC5B
  • Host species
  • Tested applications
    Suitable for: WB, ELISA, ICC/IF, IHC-FoFrmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    UNC5B Human recombinant protein.



Our Abpromise guarantee covers the use of ab104871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 104 kDa.
ELISA Use at an assay dependent concentration.
ICC/IF 1/100 - 1/500.
IHC-FoFr Use at an assay dependent concentration. PubMed: 23232257


  • Function
    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
  • Tissue specificity
    Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
  • Sequence similarities
    Belongs to the unc-5 family.
    Contains 1 death domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 TSP type-1 domains.
    Contains 1 ZU5 domain.
  • Post-translational
    Phosphorylated on cytoplasmic tyrosine residues.
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
    Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
  • Cellular localization
    Cell membrane. Membrane raft. Associated with lipid rafts.
  • Information by UniProt
  • Database links
  • Alternative names
    • 6330415E02Rik antibody
    • A630020F16 antibody
    • D10Bwg0792e antibody
    • Netrin receptor UNC5B antibody
    • Netrin receptor UNC5B Precursor antibody
    • p53 regulated receptor for death and life antibody
    • p53 regulated receptor for death and life protein 1 antibody
    • p53-regulated receptor for death and life protein 1 antibody
    • p53RDL1 antibody
    • Protein unc-5 homolog 2 antibody
    • Protein unc-5 homolog B antibody
    • Protein XUNC 5 antibody
    • Transmembrane receptor Unc5H2 antibody
    • Unc 5 homolog 2 antibody
    • Unc 5 homolog B antibody
    • Unc 5 netrin receptor B antibody
    • UNC 5B antibody
    • Unc5 (C.elegans homolog) b antibody
    • Unc5b antibody
    • UNC5B_HUMAN antibody
    • UNC5H2 antibody
    see all


  • Immunohistochemical analysis of paraformaldehyde-perfusion fixed Rat brain tissue, staining UNC5B (red) with ab104871 at 1/300 dilution.



This product has been referenced in:
  • Motherwell JM  et al. Endothelial Cell Phenotypes are Maintained During Angiogenesis in Cultured Microvascular Networks. Sci Rep 8:5887 (2018). IHC ; Rat . Read more (PubMed: 29651134) »
  • Yu J  et al. Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway. Front Neurosci 11:700 (2017). Read more (PubMed: 29311781) »

See all 4 Publications for this product

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