Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: PBS, 0.05% BSA
Concentration information loading...
PurityProtein G purified
Purification notesThis antibody is affinity purified.
Our Abpromise guarantee covers the use of ab13668 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 2 µg/ml. Detects a band of approximately 34 kDa (predicted molecular weight: 36.5 kDa).|
FunctionExcises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Tissue specificityIsoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells.
Involvement in diseaseDefects in UNG are a cause of immunodeficiency with hyper-IgM type 5 syndrome (HIGM5) [MIM:608106]. Hyper-IgM syndrome is a condition characterized by normal or increased serum IgM concentrations associated with low or absent serum IgG, IgA, and IgE concentrations. HIGM5 is associated with profound impairment in immunoglobulin (Ig) class-switch recombination (CSR) at a DNA precleavage step.
Sequence similaritiesBelongs to the uracil-DNA glycosylase family.
modificationsIsoform 1 is processed by cleavage of a transit peptide.
Cellular localizationMitochondrion and Nucleus.
- Information by UniProt
- DGU antibody
- DKFZp781L1143 antibody
- HIGM 4 antibody
This product has been referenced in:
- Pauklin S et al. Alternative induction of meiotic recombination from single-base lesions of DNA deaminases. Genetics 182:41-54 (2009). ICC/IF ; Caenorhabditis elegans . Read more (PubMed: 19237686) »
- Di Noia JM et al. Dependence of antibody gene diversification on uracil excision. J Exp Med 204:3209-19 (2007). WB ; Mouse . Read more (PubMed: 18070939) »