Anti-Unrip antibody (ab102001)
Key features and details
- Rabbit polyclonal to Unrip
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Unrip antibody
See all Unrip primary antibodies -
Description
Rabbit polyclonal to Unrip -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow -
Immunogen
Recombinant protein fragment, corresponding to a region within amino acids 25-289 of Human Unrip (AAH00162).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab102001 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (2) |
1/500 - 1/3000. Predicted molecular weight: 38 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 38 kDa. |
Target
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Function
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. -
Sequence similarities
Belongs to the WD repeat STRAP family.
Contains 7 WD repeats. -
Cellular localization
Cytoplasm. Nucleus. Localized predominantly in the cytoplasm but also found in the nucleus. - Information by UniProt
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Database links
- Entrez Gene: 510201 Cow
- Entrez Gene: 11171 Human
- Entrez Gene: 20901 Mouse
- Entrez Gene: 297699 Rat
- Omim: 605986 Human
- SwissProt: Q5E959 Cow
- SwissProt: Q9Y3F4 Human
- SwissProt: Q9Z1Z2 Mouse
see all -
Alternative names
- MAP activator with WD repeats antibody
- MAWD antibody
- PTWD antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab102001 has been referenced in 2 publications.
- Sapaly D et al. The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases. Front Mol Biosci 7:55 (2020). PubMed: 32363199
- Pruksakorn D et al. Oncogenic roles of serine-threonine kinase receptor-associated protein (STRAP) in osteosarcoma. Cancer Chemother Pharmacol 82:1039-1047 (2018). PubMed: 30276452