Overview

  • Product name
    Anti-UQCRB antibody
    See all UQCRB primary antibodies
  • Description
    Rabbit polyclonal to UQCRB
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    antigen sequence: LPENLYNDRM FRIKRALDLN LKHQILPKEQ WTKYEEENFY LEPYLKEVIR ERKEREEWAK K, corresponding to internal sequence amino acids 51-111 of Human UQCRB.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • Human colon tissue; RT 4, U 251 MG and Liver lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab122827 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

Target

  • Function
    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.
  • Involvement in disease
    Defects in UQCRB are a cause of mitochondrial complex III deficiency (MT-C3D) [MIM:124000]. A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance.
  • Sequence similarities
    Belongs to the UQCRB/QCR7 family.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • Complex III subunit 7 antibody
    • Complex III subunit VII antibody
    • Cytochrome b-c1 complex subunit 7 antibody
    • MC3DN3 antibody
    • Mitochondrial ubiquinone-binding protein antibody
    • QCR7 antibody
    • QCR7_HUMAN antibody
    • QP-C antibody
    • QPC antibody
    • Ubiquinol cytochrome c reductase complex III subunit VI antibody
    • Ubiquinol-cytochrome c reductase binding protein antibody
    • Ubiquinol-cytochrome c reductase complex 14 kDa protein antibody
    • Ubiquinone-binding protein antibody
    • UQBC antibody
    • UQBP antibody
    • UQCR6 antibody
    • UQCRB antibody
    • UQPC antibody
    see all

Images

  • Western blot - Anti-UQCRB antibody (ab122827)
    Western blot - Anti-UQCRB antibody (ab122827)
    All lanes : Anti-UQCRB antibody (ab122827) at 1/250 dilution

    Lane 1 : RT 4 lysate
    Lane 2 : U 251 MG lysate
    Lane 3 : Human plasma lysate
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

    Developed using the ECL technique.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab122827)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab122827)
    ab122827 at 1/200 dilution staining UQCRB in Paraffin-embedded Human colon tissue by Immunohistochemistry tissue.

References

ab122827 has not yet been referenced specifically in any publications.

Publishing research using ab122827? Please let us know so that we can cite the reference in this datasheet.

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