Anti-UQCRB antibody (ab229465)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-UQCRB antibody
See all UQCRB primary antibodies -
Description
Rabbit polyclonal to UQCRB -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Recombinant fragment within Human UQCRB (internal sequence). The exact sequence is proprietary.
Database link: P14927 -
Positive control
- WB: Human and mouse liver tissue extracts. IHC-P: Mouse liver and rat intestine tissues.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.025% Proclin
Constituents: PBS, 20% Glycerol -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab229465 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/100 - 1/1000. | |
| WB | 1/1000 - 1/10000. Predicted molecular weight: 14 kDa. |
Target
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Function
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. -
Involvement in disease
Defects in UQCRB are a cause of mitochondrial complex III deficiency (MT-C3D) [MIM:124000]. A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. -
Sequence similarities
Belongs to the UQCRB/QCR7 family. -
Cellular localization
Mitochondrion inner membrane. - Information by UniProt
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Database links
- Entrez Gene: 7381 Human
- Entrez Gene: 67530 Mouse
- Entrez Gene: 362897 Rat
- Omim: 191330 Human
- SwissProt: P14927 Human
- SwissProt: Q9D855 Mouse
- Unigene: 131255 Human
- Unigene: 379136 Mouse
see all -
Alternative names
- Complex III subunit 7 antibody
- Complex III subunit VII antibody
- Cytochrome b-c1 complex subunit 7 antibody
see all
Images
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Western blot - Anti-UQCRB antibody (ab229465)All lanes : Anti-UQCRB antibody (ab229465) at 1/5000 dilution
Lane 1 : Mouse liver tissue extracts at 50 µg
Lane 2 : Human liver tissue extracts at 30 µg
Predicted band size: 14 kDa15% SDS-PAGE
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab229465)Paraffin-embedded rat intestine stained for UQCRB using ab229465 at 1/500 dilution in immunohistochemical analysis.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab229465)Paraffin-embedded mouse liver tissue stained for UQCRB using ab229465 at 1/500 dilution in immunohistochemical analysis.
References
ab229465 has not yet been referenced specifically in any publications.
