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    uqcrb-antibody-ab229465.pdf

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Cardiovascular Lipids / Lipoproteins Lipid Metabolism Cytochromes
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Anti-UQCRB antibody (ab229465)

  • Datasheet
  • SDS
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Western blot - Anti-UQCRB antibody (ab229465)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab229465)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab229465)

Key features and details

  • Rabbit polyclonal to UQCRB
  • Suitable for: IHC-P, WB
  • Reacts with: Mouse, Rat, Human
  • Isotype: IgG

You may also be interested in

Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-UQCRB antibody
    See all UQCRB primary antibodies
  • Description

    Rabbit polyclonal to UQCRB
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment within Human UQCRB (internal sequence). The exact sequence is proprietary.
    Database link: P14927

  • Positive control

    • WB: Human and mouse liver tissue extracts. IHC-P: Mouse liver and rat intestine tissues.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.025% Proclin 300
    Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipid Metabolism
    • Cytochromes
    • Signal Transduction
    • Metabolism
    • Energy Metabolism
    • Signal Transduction
    • Metabolism
    • Mitochondrial
    • Cell Biology
    • Other Antibodies
    • Oxidative Stress
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
    • Mitochondrial markers
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipases
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Energy transfer pathways
    • Energy Metabolism
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
    • Cytochromes

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • Mouse liver tissue lysate - total protein (ab29301)

Applications

Our Abpromise guarantee covers the use of ab229465 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/1000 - 1/10000. Predicted molecular weight: 14 kDa.

Target

  • Function

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.
  • Involvement in disease

    Defects in UQCRB are a cause of mitochondrial complex III deficiency (MT-C3D) [MIM:124000]. A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance.
  • Sequence similarities

    Belongs to the UQCRB/QCR7 family.
  • Cellular localization

    Mitochondrion inner membrane.
  • Target information above from: UniProt accession P14927 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 7381 Human
    • Entrez Gene: 67530 Mouse
    • Entrez Gene: 362897 Rat
    • Omim: 191330 Human
    • SwissProt: P14927 Human
    • SwissProt: Q9D855 Mouse
    • Unigene: 131255 Human
    • Unigene: 379136 Mouse
    • Unigene: 105517 Rat
    see all
  • Alternative names

    • Complex III subunit 7 antibody
    • Complex III subunit VII antibody
    • Cytochrome b-c1 complex subunit 7 antibody
    • MC3DN3 antibody
    • Mitochondrial ubiquinone-binding protein antibody
    • QCR7 antibody
    • QCR7_HUMAN antibody
    • QP-C antibody
    • QPC antibody
    • Ubiquinol cytochrome c reductase complex III subunit VI antibody
    • Ubiquinol-cytochrome c reductase binding protein antibody
    • Ubiquinol-cytochrome c reductase complex 14 kDa protein antibody
    • Ubiquinone-binding protein antibody
    • UQBC antibody
    • UQBP antibody
    • UQCR6 antibody
    • UQCRB antibody
    • UQPC antibody
    see all

Images

  • Western blot - Anti-UQCRB antibody (ab229465)
    Western blot - Anti-UQCRB antibody (ab229465)
    All lanes : Anti-UQCRB antibody (ab229465) at 1/5000 dilution

    Lane 1 : Mouse liver tissue extracts at 50 µg
    Lane 2 : Human liver tissue extracts at 30 µg

    Predicted band size: 14 kDa



    15% SDS-PAGE

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab229465)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab229465)

    Paraffin-embedded rat intestine stained for UQCRB using ab229465 at 1/500 dilution in immunohistochemical analysis.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab229465)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRB antibody (ab229465)

    Paraffin-embedded mouse liver tissue stained for UQCRB using ab229465 at 1/500 dilution in immunohistochemical analysis.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab229465? Please let us know so that we can cite the reference in this datasheet.

    ab229465 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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