Overview

  • Product name

    Uracil, allosteric regulator and coenzyme
  • Description

    Allosteric regulator and coenzyme
  • Biological description

    Allosteric regulator and coenzyme. Fundamental component of RNA. Forms base pairs with adenine. Shows antitumor effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    66-22-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1H-pyrimidine-2,4-dione
  • Molecular weight

    112.09
  • Molecular formula

    C4H4N2O2
  • PubChem identifier

    1174
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM and in 1 N NaOH to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CNC(=O)NC1=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Xia B  et al. Specificity and Catalytic Mechanism in Family 5 Uracil DNA Glycosylase. J Biol Chem : (2014). Read more (PubMed: 24838246) »
  • Hasegawa N  et al. Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters. Int J Cancer 133:1479-88 (2013). Read more (PubMed: 23444104) »
  • Tsujimoto H  et al. Effect of leucovorin on the antitumor efficacy of the 5-FU prodrug, tegafur-uracil, in human colorectal cancer xenografts with various expression levels of thymidylate synthase. Oncol Lett 1:973-980 (2010). Read more (PubMed: 22870097) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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