Overview

  • Product name

    URB 597, FAAH inhibitor
  • Description

    Potent and selective FAAH inhibitor
  • Biological description

    Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 4.6 nM in brain membranes and 0.5 nM in neurons). Causes accumulation of anandamide. Displays anxiolytic, antidepressant, antinociceptive and analgesic effect.
  • Purity

    > 98%
  • General notes

    This compound has been found to be unstable in DMSO even at room temperature.

  • CAS Number

    546141-08-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Hasanein P  et al. URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats. Can J Physiol Pharmacol 87:432-9 (2009). Read more (PubMed: 19526037) »
  • Russo R  et al. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. J Pharmacol Exp Ther 322:236-42 (2007). Read more (PubMed: 17412883) »
  • Kathuria S  et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9:76-81 (2003). Read more (PubMed: 12461523) »
See 1 Publication for this product

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