Overview

  • Product name

    Urocortin II (human), CRF2 agonist
  • Description

    Selective CRF2 agonist
  • Biological description

    Selective CRF2 agonist. Urocortin (Asc 2961) analogue. Shows central autonomic, appetitive control and hemodynamic effects in vivo.
  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    4449.31
  • Molecular formula

    C194H339N63O54S
  • Sequence

    IVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC (Modifications: C-terminal amide)
  • PubChem identifier

    56843276
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Rademaker MT  et al. Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure. Circ Heart Fail 6:825-32 (2013). Read more (PubMed: 23753530) »
  • Bagosi Z  et al. The interaction of Urocortin II and Urocortin III with amygdalar and hypothalamic cotricotropin-releasing factor (CRF) - Reflections on the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Neuropeptides : (2013). Read more (PubMed: 23932308) »
  • Reyes TM  et al. Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A 98:2843-8 (2001). Read more (PubMed: 11226328) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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